ACS Publications congratulates long time authors Robert J. Lefkowitz and Brian K. Kobilka on winning the 2012 Nobel Prize in Chemistry for their studies of G-protein-coupled receptors (GPCRs).  These receptors allow cells in the body to sense and respond to outside signals and are the target for several commonly prescribed prescription drugs including beta blockers, antihistamines and antidepressants.

ACS Publications also congratulates Accounts of Chemical Research author David Wineland, on the 2012 Nobel Prize in Physics.

1975-1980 / 1981-1985 / 1986-1990 / 1991-1995 / 1996-1999 / 2002-Current 

Conformational Dynamics of Single G Protein-Coupled Receptors in Solution
Samuel Bockenhauer, Alexandre Fürstenberg, Xiao Jie Yao, Brian K. Kobilka, and W. E. Moerner
The Journal of Physical Chemistry B 2011
View article -  DOI: 10.1021/jp204843r 

Tandem Facial Amphiphiles for Membrane Protein Stabilization Pil Seok Chae, Kamil Gotfryd, Jennifer Pacyna, Larry J. W. Miercke, Søren G. F. Rasmussen, Rebecca A. Robbins, Rohini R. Rana, Claus J. Loland, Brian Kobilka, Robert Stroud, Bernadette Byrne, Ulrik Gether, and Samuel H. Gellman
Journal of the American Chemical Society 2010
View article -  DOI: 10.1021/ja1072959 

Mass Spectrometric Analysis of Agonist Effects on Posttranslational Modifications of the β2-Adrenoceptor in Mammalian Cells Michelle Trester-Zedlitz, Al Burlingame, Brian Kobilka, and Mark von Zastrow
Biochemistry 2005
View article - DOI: 10.1021/bi0475469 

Plasmon-Waveguide Resonance Studies of Ligand Binding to the Human β2-Adrenergic Receptor Savitha Devanathan, Zhiping Yao , Zdzislaw Salamon, Brian Kobilka, and Gordon Tollin
Biochemistry 2004
View article - DOI: 10.1021/bi035825a 

β2-Adrenergic Receptor Stimulated, G Protein-Coupled Receptor Kinase 2 Mediated, Phosphorylation of Ribosomal Protein P2 Jennifer L. R. Freeman, Philippe Gonzalo, Julie A. Pitcher, Audrey Claing, Jean-Pierre Lavergne, Jean-Paul Reboud, and Robert J. Lefkowitz
Biochemistry 2002
View article - DOI: 10.1021/bi020145d 

Phosphorylation of β-Arrestin2 Regulates Its Function in Internalization of β2-Adrenergic Receptors Fang-Tsyr Lin, Wei Chen, Sudha Shenoy, Mei Cong, Sabrina T. Exum, and Robert J. Lefkowitz
Biochemistry 2002
View article - DOI: 10.1021/bi025705n 

Analysis of Biomolecular Interactions Using a Miniaturized Surface Plasmon Resonance Sensor Rebecca J. Whelan, Thorsten Wohland, Lars Neumann, Bo Huang, Brian K. Kobilka and Richard N. Zare
Analytical Chemistry 2002
View article - DOI: 10.1021/ac025669y 

Restricting the Mobility of Gsα: Impact on Receptor and Effector Coupling
Tae Weon Lee, Roland Seifert, Xiaoming Guan, and Brian K. Kobilka
Biochemistry 1999
View article - DOI: 10.1021/bi9908282 

Palmitoylation Increases the Kinase Activity of the G Protein-Coupled Receptor Kinase, GRK6 Robert H. Stoffel, James Inglese, Alexander D. Macrae, Robert J. Lefkowitz and Richard T. Premont
Biochemistry 1998
View article - DOI: 10.1021/bi981432d 

Ligand Stabilization of the β2 Adrenergic Receptor:  Effect of DTT on Receptor Conformation Monitored by Circular Dichroism and Fluorescence Spectroscopy Sansan Lin, Ulrik Gether, and Brian K. Kobilka
Biochemistry 1996
View article - DOI: 10.1021/bi961619+ 

Ras-Dependent Activation of Fibroblast Mitogen-Activated Protein Kinase by 5-HT1A Receptor via a G Protein βγ-Subunit-Initiated Pathway Maria N. Garnovskaya, Tim van Biesen, Brian Hawes, Shirley Casañas Ramos, Robert J. Lefkowitz and John R. Raymond
Biochemistry 1996
View article - DOI: 10.1021/bi961764n 

Members of the G Protein-Coupled Receptor Kinase Family That Phosphorylate the β2-Adrenergic Receptor Facilitate Sequestration Luc Ménard, Stephen S. G. Ferguson, Larry S. Barak, Lucie Bertrand, Richard T. Premont, Anne-Marie Colapietro, Robert J. Lefkowitz and Marc G. Caron
Biochemistry 1996
View article - DOI: 10.1021/bi952961+ 

Desensitization of the Isolated β2-Adrenergic Receptor by β-Adrenergic Receptor Kinase,cAMP-Dependent Protein Kinase, and Protein Kinase C Occurs viaDistinct Molecular Mechanisms Julie Pitcher, Martin J. Lohse, Juan Codina,Marc G. Caron, and Robert J. Lefkowitz
Biochemistry 1992
View article - DOI: 10.1021/bi00127a021 

Role of Acidic Amino Acids in Peptide Substrates of the β-Adrenergic Receptor Kinase and Rhodopsin Kinase
James J. Onorato, Krzysztof Palczewski, John W. Regan, Marc G. Caron, Robert J. Lefkowitz, and Jeffrey L. Benovic
Biochemistry 1991
View article - DOI: 10.1021/bi00235a002 

Functional Interactions of Recombinant α2 Adrenergic Receptor Subtypes and G Proteins in Reconstituted Phospholipid Vesicles
Hitoshi Kurose, John W. Regan, Marc G. Caron,and Robert J. Lefkowitz
Biochemistry 1991
View article - DOI: 10.1021/bi00227a024 

Role of Extracellular Disulfide-Bonded Cysteines in the Ligand Binding Function of the β2-Adrenergic Receptor
Henrik G. Dohlman, Marc G. Caron, Antonio DeBlasi, Thomas Frielle, and Robert J. Lefkowitz
Biochemistry 1990
View article - DOI: 10.1021/bi00461a018 

Localization of the Fourth Membrane spanning Domain as a Ligand Binding Site in the Human Platelet α2-Adrenergic Receptor Hiroaki Matsui, Robert J. Lefkowitz, Marc G. Caron, and John W. Regan
Biochemistry 1989
View article - DOI: 10.1021/bi00435a075 

Phosphorylation of Chick Heart Muscarinic Cholinergic Receptors by the β-Adrenergic Receptor Kinase Madan M. Kwatra, Jeffrey L. Benovic, Marc G. Caron, Robert J. Lefkowitz, and M. Marlene Hosey
Biochemistry 1989
View article - DOI: 10.1021/bi00437a005 

Identification and Sequence of a Binding Site Peptide of the β2-Adrenergic Receptor Henrik G. Dohlman, Marc G. Caron, Catherine D. Strader, Nourdine Amlaiky, and Robert J. Lefkowitz
Biochemistry 1988
View article - DOI: 10.1021/bi00406a002 

A Family of Receptors Coupled to Guanine Nucleotide Regulatory Proteins Henrik G. Dohlman, Marc G. Caron, and Robert J. Lefkowitz
Biochemistry 1987
View article - DOI: 10.1021/bi00384a001 

Functional Differences in the βγ Complexes of Transducin and the Inhibitory Guanine Nucleotide Regulatory Protein Richard A. Cerione, Peter Gierschik, Claudia Stanizsewski, Jeffrey L. Benovic, Juan Codina, Robert Somers, Lutz Birnbaumer, Allen M. Spiegel, Robert J. Lefkowitz, and Marc G. Caron
Biochemistry 1987
View article - DOI: 10.1021/bi00379a041 

A Novel Catecholamine-Activated Adenosine Cyclic 3',5'-Phosphate Independent Pathway for β-Adrenergic Receptor Phosphorylation in Wild-Type and Mutant S49 Lymphoma Cells: Mechanism of Homologous Desensitization of Adenylate Cyclase Ruth H. Strasser, David R. Sibley, and Robert J. Lefkowitz
Biochemistry 1986
View article - DOI: 10.1021/bi00354a027 

Transducin and the Inhibitory Nucleotide Regulatory Protein Inhibit the Stimulatory Nucleotide Regulatory Protein Mediated Stimulation of Adenylate Cyclase in Pospholipid Vesicle Systems Richard A. Cerione, Juan Codina, Brian F. Kilpatrick, Claudia Staniszewski, Peter Gierschik, Robert L. Somers, Allen M. Spiegel, Lutz Birnbaumer, Marc G. Caron, and Robert J. Lefkowitz
Biochemistry 1985
View article - DOI: 10.1021/bi00338a00 

The Mammalian β2-Adrenergic Receptor: Reconstitution of Functional Interactions Between Pure Receptor and Pure Stimulatory Nucleotide Binding Protein of the Adenylate Cyclase System Richard A. Cerione, Juan Codina, Jeffrey L. Benovic, Robert J. Lefkowitz, Lutz Birnbaumer, and Marc G. Caron
Biochemistry 1984
View article - DOI: 10.1021/bi00315a003 

The Mammalian β2-Adrenergic Receptor: Purification and Characterization Jeffrey L. Benovic, Robert G. L. Shorr, Marc G. Caron, and Robert J. Lefkowitz
Biochemistry 1984
View article - DOI: 10.1021/bi00315a002 

Determination of the Molecular Size of Frog and Turkey Erythrocyte β-Adrenergic Receptors by Radiation Inactivation Robert G. L. Shorr, Ellis S. Kempner, Mark W. Strohsacker, Ponnal Nambi, Robert J. Lefkowitz, and Marc G. Caron
Biochemistry 1984
View article - DOI: 10.1021/bi00299a025 

Synthesis of Iodine-125 labeled (+-)-15-[4-Azidobenzyl]carazolol: A Potent β-Adrenergic Photoaffinity Probe Sarah L. Heald, Peter W. Jeffs, Thomas N. Lavin, Ponnal Nambi, Robert J. Lefkowitz, and Marc G. Caron
Journal of Medicinal Chemistry 1983
View article - DOI: 10.1021/jm00360a009 

Parallel Modulation of Catecholamineactivation of Adenylate Cyclase and Formation of the High-Affinity Agonist Receptor Complex in Turkey Erythrocyte Membranes by Temperature and cis-Vaccenic Acid
Margaret M. Briggs and Robert J. Lefkowitz
Biochemistry 1980
View article - DOI: 10.1021/bi00560a012 

Structure and Biological Activity of(-)-[3H]-Dihydroalprenolol, a Radioligand for Studies of β-Adrenergic Receptors
Malcolm H. Randall, Lawrence J. Altman, and Robert J. Lefkowitz
Journal of Medicinal Chemistry 1977
View article - DOI: 10.1021/jm00218a020 

Pharmacological Activity of Nitroxide Analogs of Dichloroisoproterenol and Propranolol
Elmer J. Rauckman, Gerald M. Rosen, and Robert J. Lefkowitz
Journal of Medicinal Chemistry 1976
View article - DOI: 10.1021/jm00232a018